Which layer of the epidermis is responsible for cell division and regeneration?
A. Stratum corneum
B. Stratum granulosum
C. Stratum basale
D. Stratum lucidum
ANSWER: C
Which layer of the skin is responsible for insulating the body and storing fat?
A. Epidermis
B. Dermis
C. Hypodermis
D. Stratum basale
ANSWER: C
The sensation of touch is detected by which type of sensory receptors in the skin?
A. Photoreceptors
B. Thermoreceptors
C. Mechanoreceptors
D. Nocireceptors
ANSWER: C
Choose the correct sequence of arrangement of layers of Dermoepidermal junction
A. Basal keratinocytes, laminate lucida, hemidesmosomes, laminate densa, anchoring fibrils
B. Laminate densa, lamina lucida, hemidesmosomes, anchoring fibrils, basal keratinocytes
C. Basal keratinocytes, hemidesmosomes, lamina lucida, lamina densa, anchoring fibrils
D. Lamina lucida, lamina densa, hemidesmosomes, anchoring fibrils, basal keratinocytes
ANSWER: C
Which of the following is major component of Lamina densa?
A. Type IV collagen
B. Type I collagen
C. Type III collagen
D. Type II collagen
ANSWER: A
In which of the following stages of hair cycle is the hair follicle empty?
A. Anagen
B. Catagen
C. Telogen
D. Kenogen
ANSWER: D
Which part of nail anatomy is responsible for producing new nail cells ?
A. Nail bed
B. Nail plate
C. Nail matrix
D. Cuticle
ANSWER: C
Which of the following areas mainly contains Eccrine sweat glands?
A. Chest and abdomen
B. Palms and soles
C. Armpits and groin
D. Scalp
ANSWER: B
Apocrine sweat glands active during?
A. Puberty
B. Infancy
C. Before birth
D. Menopause
ANSWER: A
What is the scientific name of the nine-banded armadillo?
A. Dasypus septemcinctus
B. Dasypus novemcinctus
C. Mus musculus
D. Macaca mulatta
ANSWER: B
"Claw hand deformity" is due to involvement of which nerve?
A. Median nerve alone
B. Ulnar and Median nerves
C. Radial nerve
D. Lateral cutaneous nerve of forearm
ANSWER: B
Exclamation mark hair on dermoscopy is characteristic of which condition?
A. Telogen Effluvium
B.Alopecia Areata
C. Tinea Capitis
D. Trichorrhexis Nodosa
ANSWER: B
Primary biochemical defect in Menkes disease is?
A. Impaired copper transporters
B. Deficiency of tyrosine hydroxylase
C. Impaired collagen synthesis
D. Decreased activity of cytochrome P450 enzymes
ANSWER: A
Most common type of onychomycosis is?
A. Distal and lateral subungual
B. Proximal subungual
C. Superficial
D. Endonyx
ANSWER: A
In systemic sclerosis, which antibody is most strongly associated with pulmonary arterial hypertension (PAH)?
A. Anti-Scl-70
B. Anti-centromere
C. Anti-RNA polymerase III
D. Anti-U3 RNP
ANSWER: B
Groove sign of Greenblatt is seen in which condition?
A. Syphilis
B. Herpes genitalis
C. Chancroid
D. Lymphogranuloma venereum (LGV)
ANSWER: D
Which one is the most
common type of basal cell carcinoma?
A. Superficial
B. Nodular
C. Infiltrative
D. Morpheaform
ANSWER: B
Which of the following human papillomavirus (HPV) types are most often responsible for causing genital warts?
A. HPV 6 and 11
B. HPV 16 and 18
C. HPV 31 and 33
D. HPV 45 and 52
ANSWER: A
Which of the following infections is most commonly associated with a frothy, greenish-yellow vaginal discharge?
A. Bacterial vaginosis
B. Candidiasis
C. Trichomoniasis
D. Gonorrhea
ANSWER: C
Which test is used to diagnose bacterial vaginosis by detecting a fishy odour when KOH is added to a vaginal sample?
A. Pap smear
B. Whiff test
C. Wet mount
D. Gram stain
ANSWER: B
Which of the following is associated with the "breakfast, lunch, dinner" sign?
A. Flea bite
B. Spider bite
C. Bed bug bite
D. Caterpillar bite
ANSWER: C
What is the "Circle of Hebra"?
A. It is an imaginary circle intersecting the main sites of involvement in scabies
B. An imaginary circle that extends from the ala of the nose to the tragus of the ear.
C. The line midway between the nipple and the border of the sternum.
D. A line running in the main axis of the body or a body part, such as a limb.
ANSWER: A
Chronic urticaria is defined as the occurrence of hives for more than:
A. 1 week
B. 3 weeks
C. 6 weeks
D. 12 weeks
ANSWER: C
The wheals in chronic spontaneous urticaria typically:
A. Appear after food intake
B. Resolve within 24 hours
C. Are associated with fever
D. Are painful rather than itchy
ANSWER: B
The autologous serum skin test (ASST) is primarily used to diagnose:
A. Physical urticaria
B. Autoimmune urticaria
C. Acute urticaria
D. Chronic inducible urticaria
ANSWER: B
Which gene mutation is associated with Darier's disease?
A. ATP2A2
B. KRT5
C. TP53
D. COL7A1
ANSWER: A
Which of the following conditions is inherited in an X-linked dominant manner?
A. Incontinentia pigmenti
B. Epidermolysis bullosa
C. Neurofibromatosis type 1
D. Tuberous sclerosis
ANSWER: A
Which of the following is a characteristic feature of tuberous sclerosis complex?
A. Café-au-lait spots
B. Ash leaf macules
C. Lisch nodules
D. Neurofibromas
ANSWER: B
Which condition is characterized by the presence of multiple basal cell carcinomas and jaw cysts?
A. Gorlin syndrome
B. Peutz-Jeghers syndrome
C. Cowden syndrome
D. Li-Fraumeni syndrome
ANSWER: A
Which of the following is a feature of neurofibromatosis type 1?
A. Café-au-lait spots
B. Lisch nodules
C. Neurofibromas
D. All of the above
ANSWER: D
Which of the following is
used to assess severity in atopic dermatitis?
A. PASI score
B. DLQI
C. SCORAD
D. GAGS
ANSWER: C
Which investigation is
MOST helpful in differentiating allergic and irritant contact dermatitis?
A. Culture
B. Biopsy
C. Patch test
D. Blood eosinophil count
ANSWER: C
What is the underlying
enzyme defect in classic phenylketonuria?
A. Tyrosinase
B. Homogentisic acid oxidase
C. Phenylalanine hydroxylase
D. Glucose-6-phosphatase
ANSWER: C
Necrobiosis lipoidica is
most commonly associated with:
A. Hypothyroidism
B. Addison’s disease
C. Diabetes mellitus
D. Cushing’s syndrome
ANSWER: C
Which of the following is a cutaneous manifestation of scurvy?
A. Follicular hyperkeratosis
B. Corkscrew hairs and perifollicular hemorrhages
C. Pellagroid rash
D. Hyperpigmentation of knuckles
ANSWER: B
Which of the following is a feature of glucagonoma syndrome?
A. Acanthosis nigricans
B. Necrolytic migratory erythema
C. Porphyrinuria
D. Lipodystrophy
ANSWER: B
Tokelau is a synonym of
A. Tinea Circinata
B. Tinea Incognito
C. Tinea Imbricata
D. Tricophytic granuloma
ANSWER: C
On histopathological examination, "Ball in Clutch" appearance is described in
A. Pityriasis Rubra Pilaris
B. Lichen Nitidus
C. Lichen Amyloidosis
D. Discoid Lupus Erythematosus
ANSWER: B
HLA-B27 is associated with
A. Systemic Lupus Erythematosus
B. Pityriasis Rubra Pilaris
C. Reiter's syndrome
D. Pemphigus Vulgaris
ANSWER: C
Intra-Epidermal Microabscesses are seen in all except
A. Psoriasis
B. Mycosis Fungoides
C. Reiter's syndrome
D. Lichen Planus
ANSWER: D
Texier disease occurs due
to
A. Injection of mineral oil
B. Injection of phytomenadione
C. Injection of BCG
D. Injection of glatiramer acetate
ANSWER: B
Gopalan syndrome occurs
due to deficiency of
A. Niacin
B. Riboflavin
C. Pantothenic acid
D. Vitamin Apical pleural thickening
ANSWER: C
Chelation of trivalent
metal cations, thereby causing inhibition of metal‐dependent enzymes is the
main mechanism of action of
A. Amorolfine
B. Ciclopirox Olamine
C. Tavaborole
D. Tolnaftate
ANSWER: B
VIDA score of +2 implies disease activity in past
A. 9-12 months
B. 6-9 months
C. 3-6 months
D. 6 weeks to 3 months
E. 6 weeks or less
ANSWER: C
Jodhpur technique used in vitiligo surgery is an
A. Non-cultured, trypsinised grafting technique
B. Non-cultured, non-trypsinised grafting technique
C. Cultured, non-trypsinised grafting technique
D. Cultured, trypsinised grafting technique
ANSWER: B
Sclerosants with detergent
type of mechanism includes all of the following except
A. Sodium tetradecyl sulfate
B. Ethanolamine oleate
C. Polyiodinated iodine
D. Sodium morrhuate
ANSWER: C
Condition with level of split at lamina lucida
A. Dermatitis herpetiformis
B. Bullous SLE
C. Epidermolysis bullosa acquisita
D. Bullous amyloidosis
ANSWER: A
Variegate porphyria is due to deficiency of
A. Coproporphyrinogen
B. Porphobilinogen deaminase
C. Uroporphyrinogen decarboxylase
D. Protoporphyrinogen oxidase
ANSWER: D
Nail finding in psoriasis due to involvement of intermediate matrix
A. Pitting
B. Beau’s lines
C. Leukonychia
D. Salmon patch
ANSWER: C
CD 31 positive staining on immunohistochemistry is seen in
A. Melanoma
B. Leiomyosarcoma
C. Angiosarcoma
D. Squamous cell carcinoma
ANSWER: C
Molecular weight of
plectin is
A. 190 kDa
B. 300 kDa
C. 500 kDa
D. 210 kDa
ANSWER: C
Regarding HLA association and drug hypersensitivity syndrome, which one is wrongly paired
A. HLA-A*3101 and carbamazepine
B. HLA-B*1502 and allopurinol
C. HLA-B*5701 and abacavir
D. HLA-B*1301 and dapsone
ANSWER: B
World vitiligo day is observed on
A. May 25th
B. June 25th
C. July 25th
D. August 25th
ANSWER: B
Which of the following is not included in the diagnostic criteria of Kawasaki disease
A. Bilateral nonexudative conjunctival injection
B. Cardiac aneurysm
C. Fever for 5 days or more
D. Maculopapular, or erythema multiforme-like rash
ANSWER: B
What is plumber's itch
A. Tinea Pedis
B. Scabies
C. Candidiasis
D. Cutaneous larva migrans
ANSWER: D
Newborn child affected
with congenital syphilis never causes ulceration of the breast which it sucks,
if it is the mother who suckles it, though continuing capable of infecting a
strange nurse is
A. Diday-kassowitz law
B. Baumis law
C. Profeta’s law
D. Fournier-finger criteria
ANSWER: B
Who first used chemical peels?
A. Unna
B. Fox
C. Von hebra
D. Baker and Gordon
ANSWER: C
What is the typical wavelength of a CO, laser?
A. 532 nm
B. 808 nm
C. 10,600 nm
D. 1064 nm
ANSWER: C
Which of the following is a beta-hydroxy acid (BHA) used in chemical peels?
A. Glycolic acid
B. Salicylic acid
C. Lactic acid
D. TCA
ANSWER: B
What is the primary chromophore targeted by the pulsed dye laser?
A. Melanin
B. Haemoglobin
C. Water
D. Collagen
ANSWER: B
Frog spawn appearance on dermoscopy is seen in
A. Lymphangioma circumscriptum
B. Myiasis
C. Demodicidosis
D. Common wart
ANSWER: D
Condylomata lata are seen in all except
A. Venereal Syphilis
B. Yaws
C. Pinta
D. Endemic syphilis
ANSWER: C
Treatment of methemoglobinemia in G6PD deficient patient
A. Methylene blue
B. N-acetyl cysteine
C. Glutathione
D. Ascorbic acid
ANSWER: D
Sake, A rice wine, is associated with
A. Mandelic acid
B. Kojic acid
C. Arbutin
D. Tranexamic acid
ANSWER: B
Emperipolesis is a characteristic feature of
A. Langerhan cell histiocytosis
B. Multicentric reticulate histiocytosis
C. Rosai – dorfman disease
D. Malignant histiocytosis
ANSWER: C
Eye liner sign is seen in
A. Squamous cell carcinoma
B. Basal cell carcinoma
C. Bowen’s disease
D. Actinic keratoses
ANSWER: C
Glass tongue is seen with
A. Myxedema
B. Sarcoidosis
C. Tertiary syphilis
D. Systemic sclerosis
ANSWER: C
Pohl pinkus nodes of hair are analogous to
A. Mee’s lines
B. Beau’s lines
C. Muehrcke’s lines
D. Tory’s lines
ANSWER: B
Glogau’s classification is widely used for
A. Pigmentation Severity
B. Laser parameters for Tattoo
C. Photoaging
D. Acne scarring
ANSWER: C
Nevus araneus is nothing but
A. Spitz nevus
B. Halo nevus
C. Spider nevus
D. Junctional nevus
ANSWER: C
Fried Egg appearance is seen with
A. Mast cell
B. Histiocyte
C. Langhans Giant cell
D. Sertolli rosette
ANSWER: A
Which one of the following causes Pityriasis rosea like eruption?
A. Ranitidine
B. Isotretinoin
C. Hydralazine
D. Doxycycline
ANSWER: B
Degradation product of
180KD bullous pemphigoid antigen
A. Plectin
B. Ladinin
C. α6β4 integrin
D. Laminin
ANSWER: B
Mutation of the β4 subunit
of α6β4 integrin leads to
A. Junctional EB Herlitz
B. Dystrophic EB
C. Junctional EB with pyloric atresia
D. Generalised atrophic benign EB
ANSWER: C
IgA autoantibodies at the
tip of dermal papillae seen in
A. Gomm-Button disease
B. Linear IgA dermatosis
C. Duhring-Brocq disease
D. IgA pemphigus
ANSWER: C
All are anti-CD20
monoclonal antibodies except
A. Veltuzumab.
B. Ocrelizumab.
C. Inebilizumab.
D. Obinutuzumab.
ANSWER: C
The risk of anaphylaxis
from intravenous immunoglobulin is greatly increased in patients with
A. Chronic active hepatitis.
B. Mixed connective tissue disease.
C. Selective immunoglobulin A deficiency.
D. Autoimmune thyroiditis.
ANSWER: C
The following are the
substrates used in BIOCHIP mosaic slides except
A. C-terminal globular domain of BP230
B. membrane-bound Dsc 1 ectodomain
C. recombinant BP180 NC16A
D. membrane-bound Dsg 3 ectodomain
ANSWER: B
Ibrutinib acts through
A. Inhibit stimulatory signals provided by CD19 to B-cells and plasma cells.
B. Inhibits stimulatory signals provided by CD20 to memory B-cells, causes depletion of memory B-cells.
C. Inhibits B cell receptor and fcγr signaling through inhibition of Bruton’s tyrosine kinase.
D. Augments inhibitory signals provided by CD-22 to B-cells.
ANSWER: C
Which substrate is recommended for pemphigus foliaceus in indirect immunofluorescence?
A. Human skin
B. Guinea pig esophagus
C. Both
D. None
ANSWER: C
False statement about Kindler syndrome
A. Autosomal recessive disorder
B. Skin fragility and photosensitivity worsens over time
C. Increased risk of cutaneous squamous cell carcinoma
D. Ultra structurally, basement membrane reduplication and mixed planes of cleavage
ANSWER: B
Rituximab doesn’t act on which stage of B cells
A. Pre-B cell
B. Pro-B cell
C. Immature B cells
D. Memory B cells
ANSWER: B
Which drug should not be a first-line therapy in reproductive age group
A. Azathioprine
B. Dapsone
C. Cyclosporine
D. Cyclophosphamide
ANSWER: D
After inflating the blood pressure cuff between systolic and diastolic blood pressure for 5 mins, more than 20 petechiae per square inch are seen. This phenomen is called as
A. Mayerson phenomenon
B. Rumpel Leede phenomenon
C. Mauserung phenomenon
D. Harlequin phenomenon
ANSWER: B
Riccardi classified neurofibroma (NF) 6 as
A. Atypical NF
B. Familial NF
C. Segmental NF
D. Late onset NF
ANSWER: B
In papillon lefevre syndrome, periodontitis, gingivitis, loss of teeth, recurrent pyogenic infections are seen due to mutation in
A. SLURP -1
B. Connexin 26
C. Cathepsin C
D. Plakoglobin
ANSWER: C
Dimethylglyoxime spot test is used to detect which of the following
A. Chromium
B. Cobalt
C. Aluminium
D. Nickel
ANSWER: D
Which of the following statements is false regarding solar urticaria
A. Allergen in present in both solar urticaria patients and normal subjects in type 2 solar urticaria.
B. Specific photoallergen is present in type 1 solar urticaria patients.
C. Secondary urticaria is very common and is IgE mediated.
D. Histopathology of earlier lesion reveals perivascular neutrophilic and eosinophilic infiltrate with dermal edema separating the collagen bundles.
ANSWER: C
Which of the following is false about sunscreens
A. Tinosorb M is used as broad-spectrum sunscreen
B. Trolamine salicylate has high substantivity
C. Avobenzone enhances the degradation of octinoxate
D. PABA is safer
ANSWER: D
Graham-Little-Piccardi-Lassueur syndrome comprises all of the following except
A. Follicular LP involving the scalp or body
B. Cicatricial alopecia of the scalp
C. Cicatricial alopecia of the axillae
D. Non cicatricial alopecia of pubic areas
ANSWER: C
Which wavelength Q switch laser does not remove green colour tattoo?
A. 532 nm
B. 755 nm
C. 694 nm
D. 660 nm
ANSWER: A
Chancroid mouvolant is
A. Dwarf chancroid
B. Transient chancroid
C. Granulomatous chancroid
D. Mixed chancroid
ANSWER: B
Which of the following patterns is not seen in onychomycosis on oncychoscopy
A. Sagrada familia pattern
B. Aurora borealis pattern
C. Chick pea flour pattern
D. Ruin pattern
ANSWER: A
Which color-coded syndromic kit is used for urethral discharge in males?
A. Grey Kit
B. Green Kit
C. Yellow Kit
D. White Kit
ANSWER: A
S-100 is a marker for all of the following except?
A. Sarcoma
B. Langerhans cell histiocytosis
C. Neural tumours
D. Melanoma
ANSWER: A
Black peel is derived from
A. Almonds
B. Grapes
C. Rice
D. Azelaic acid
ANSWER: C
Lepra manchada is
A. Lucio's Phenomenon
B. Lucio Leprosy
C. Beautiful Leprosy
D. Lazarine leprosy
ANSWER: A
Inflammation of BCG scar can be one of the earliest features of
A. Kawasaki disease
B. Blau syndrome
C. Cold-associated periodic fever syndrome
D. Neonatal lupus erythematosus
ANSWER: A
All of the following are Dermal Melanocytosis except
A. Nevus of Ota
B. Mongolian spot
C. Nevus of Ito
D. Ephelids
ANSWER: D
Wood's filter is made of barium silicate and
A. 0.9% Nickel oxide
B. 9% Nickel oxide
C. 2.9% Nickel oxide
D. 9.5% Nickel oxide
ANSWER: B